We assessed fatal drug overdose and poisoning case surveillance by a r
egional poison control center, comparing it with medical examiner dete
rminations of death by poisoning over the same 2-year period and from
the same catchment area. We studied 358 fatal cases of poisoning or dr
ug overdose reported by a medical examiner and 10 fatal cases of poiso
ning or drug overdose reported by a poison control center, analyzing d
emographics and other case-associated factors with possible successful
poison control center case surveillance. Of the medical examiner case
s, 245 (68%) were prehospital deaths. Of the remaining 113 emergency d
epartment or hospital cases, only 5 (4.4%) were also reported to the p
oison control center. Compared with cases involving illicit drugs, oth
er narcotics, and sedative drugs, those that involved other prescripti
on drugs (relative odds, 30.6; 95% confidence interval, 2.7 to 351) an
d over-the-counter products and other substances (odds ratio, 18.9; 95
% confidence interval, 1.4 to 257) were significantly more likely to b
e reported to the poison control center. Most fatal cases of poisoning
and drug overdose are not detected through poison control center surv
eillance. For prevention and treatment, health planners and policy mak
ers should recognize the implications of case underreporting.