EFFECTS OF KAINIC ACID-INDUCED SEIZURES ON IMMEDIATE-EARLY GENE-EXPRESSION IN MICE WITH A TARGETED MUTATION OF THE CREB GENE

Citation
Ja. Blendy et al., EFFECTS OF KAINIC ACID-INDUCED SEIZURES ON IMMEDIATE-EARLY GENE-EXPRESSION IN MICE WITH A TARGETED MUTATION OF THE CREB GENE, Brain research, 681(1-2), 1995, pp. 8-14
Citations number
38
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
681
Issue
1-2
Year of publication
1995
Pages
8 - 14
Database
ISI
SICI code
0006-8993(1995)681:1-2<8:EOKASO>2.0.ZU;2-M
Abstract
The present study examined the response of immediate early genes follo wing kainic acid induced seizures in mice lacking the alpha and delta isoforms of CREB. mRNA levels for c-fos, c-jun, and Krox-24 were measu red following limbic seizure activity and were found to be induced in wild type as well as CREB mutant mice. This effect was also seen for t hese three mRNAs at the protein level as well as for FOS-B. Furthermor e the time course of expression of FOS, JUN, KROX-24, and FOS-B protei ns were essentially the same in CREB mutant mice as compared to wild-t ype controls. These data suggest that CREB alpha and delta are not req uired for the induction of immediate early genes following pharmacolog ically induced seizures.