Ja. Blendy et al., EFFECTS OF KAINIC ACID-INDUCED SEIZURES ON IMMEDIATE-EARLY GENE-EXPRESSION IN MICE WITH A TARGETED MUTATION OF THE CREB GENE, Brain research, 681(1-2), 1995, pp. 8-14
The present study examined the response of immediate early genes follo
wing kainic acid induced seizures in mice lacking the alpha and delta
isoforms of CREB. mRNA levels for c-fos, c-jun, and Krox-24 were measu
red following limbic seizure activity and were found to be induced in
wild type as well as CREB mutant mice. This effect was also seen for t
hese three mRNAs at the protein level as well as for FOS-B. Furthermor
e the time course of expression of FOS, JUN, KROX-24, and FOS-B protei
ns were essentially the same in CREB mutant mice as compared to wild-t
ype controls. These data suggest that CREB alpha and delta are not req
uired for the induction of immediate early genes following pharmacolog
ically induced seizures.