CLONING OF THE RAT ANGIOTENSIN-II TYPE-2 RECEPTOR GENE AND IDENTIFICATION OF ITS FUNCTIONAL PROMOTER REGION

Authors
KOBAYASHI S OHNISHI J NIBU Y NISHIMATSU S UMEMURA S ISHII M MURAKAMI K MIYAZAKI H
Citation
S. Kobayashi et al., CLONING OF THE RAT ANGIOTENSIN-II TYPE-2 RECEPTOR GENE AND IDENTIFICATION OF ITS FUNCTIONAL PROMOTER REGION, Biochimica et biophysica acta, N. Gene structure and expression, 1262(2-3), 1995, pp. 155-158
Citations number
21
Categorie Soggetti
Biology,Biophysics,"Biothechnology & Applied Migrobiology
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1262
Issue
2-3
Year of publication
1995
Pages
155 - 158
Database
ISI
SICI code
0167-4781(1995)1262:2-3<155:COTRAT>2.0.ZU;2-7
Abstract
We have cloned the rat angiotensin II receptor type 2 (AT(2)) gene, wh ose physiological function remains unclear. Sequence analysis indicate d that exons 1 and 2 exist in the 5'-untranslated region and the initi ation codon ATG is located in exon 3. The 1.6-kb genomic fragment at p ositions -1567 to +26 relative to the putative transcription start sit e was found to contain a functional promoter region using transient ch loramphenicol acetyltransferase assay. This is the first report demons trating the nucleotide sequence of the promoter region of this gene.