CUTANEOUS LOCAL NECROSIS FOLLOWING INTERF ERON-BETA INJECTIONS

Introduction. Skin necrosis al the site of interferon injections is un usual. With beta-interferon, it has been observed with high doses rang ing from 90 to 180 millions daily. Case report. Is reported a case of abdominal skin necrosis following 6 months treatment with beta-interfe ron injections, 9 millions 3 times a week, in a 56 years-old man with chronic type C hepatitis. Histological analysis showed fibrin thrombos is of deep dermal vessels. There was no coagulation abnormality. Discu ssion. The mechanisms of the interferon induced skin necrosis are disc ussed.