SUCCESSFUL TREATMENT OF INVASIVE ASPERGILLOSIS COMPLICATING PROLONGEDTREATMENT-RELATED NEUTROPENIA IN ACUTE MYELOGENOUS LEUKEMIA WITH AMPHOTERICIN-B LIPID COMPLEX

Herein we report the successful treatment of invasive aspergillosis wi th the liposomal amphotericin B (AMB) formulation, Amphotericin and Li pid Complex (ABLC(TM)). This investigational compound was employed in a 50-year-old patient with acute myelomonocytic leukemia complicated b y prolonged, treatment-induced granulocytopenia and documented Aspergi llus flavus sinusitis with signs of disseminated aspergillosis. The pa tient demonstrated radiographic signs of pulmonary aspergillosis and b iochemical signs of hepatic involvement that were resistant to a 23 da y course of conventional AMB (Fungizone(R)) therapy. Following therapy with ABLC(TM) her fever abated, her chest X-ray findings improved, an d her hepatic function tests improved with eventual resolution. (C) 19 95 Wiley-Liss, Inc.