HETEROLIGNANOLIDES - ANTITUMOR-ACTIVITY O F FURYL-ANALOG, THIENYL-ANALOG, AND PYRIDYL-ANALOG OF LIGNANOLIDES

A new class of heteroaromatic analogs of lignans, called heterolignano lides, have been tested against several tumor cell lines. These compou nds carry diverse heterocyclic rings, instead of the trimethoxyphenyl ring found in the natural lignans yatein and podorhizol. They have mod erate antineoplastic activity (P-388, A-549, HT-29) compared with that of yatein. None of the tested compounds has discernible antiviral (HS V-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activity.