ADENOSARCOMA OF THE UTERINE CERVIX - A CLINICOPATHOLOGICAL STUDY OF 12 CASES

The clinical and pathologic features of 12 cervical adenosarcomas from the files of the Armed Forces Institute of Pathology are described. T he patients ranged in age from 13 to 67 years (mean 37). The majority (58%) presented with abnormal bleeding. All tumors were located in the cervix and consisted of soft, tan, polypoid or papillary masses rangi ng in size from 1.5 to 4.5 cm. Microscopically, they showed a biphasic pattern with mesenchymal and epithelial components. There was a chara cteristic stromal condensation below the epithelial surface and around glandular structures. The cytologic atypia of stromal cells was 1+ in three, 2+ in five, and 3+ in four. The mitotic activity ranged from f our to 28 (mean 7.0) mitotic figures per 10 high-power fields. One neo plasm contained cartilage and one striated muscle. Myometrial invasion was present in three. Treatment consisted of hysterectomy in nine pat ients and excisional biopsy in three. Two patients received radiothera py; one before surgery and the other after hysterectomy. Two were trea ted with chemotherapy. Follow-up ranged from 9 months to 18.8 years. N ine patients were alive and well with no evidence of recurrent tumor a t postoperative intervals of 0.8-18.8 years. One patient died 1 year a fter diagnosis with intraabdominal metastasis. One developed a recurre nt tumor. This study demonstrates a favorable prognosis for patients w ith cervical adenosarcoma. Similar to patients with uterine adenosarco ma, prognosis is mostly affected by the presence of deep myometrial in vasion.