Mf. Townsend et al., BONE-FRACTURES ASSOCIATED WITH LUTEINIZING-HORMONE-RELEASING HORMONE AGONISTS USED IN THE TREATMENT OF PROSTATE CARCINOMA, Cancer, 79(3), 1997, pp. 545-550
BACKGROUND, Luteinizing hormone-releasing hormone agonists (LHRH-a) ha
ve become an established treatment for certain patients with prostate
carcinoma. LHRH-a are known to decrease bone mineral density. The purp
ose of this study was to determine the risk of bone fracture in men re
ceiving LHRH-a for prostate carcinoma. METHODS, A retrospective chart
review and phone interviews were conducted to determine the incidence
of bone fractures occurring in patients receiving LHRH-a for the treat
ment of prostate carcinoma. Abstracted data included the number of mon
thly LHRH-a injections, age, clinical stage of disease, sites of metas
tases, and bone fracture history. RESULTS, Twenty of the 224 patients
(9%) treated with LHRH-a for prostate carcinoma between 1988 and 1995
at 3 teaching hospitals had at least 1 bone fracture during treatment
with LHRH-a. The duration of treatment to the time of fracture ranged
from 1 to 96 months (mean, 22.2 months). Seven fractures (32%) were os
teoporotic in nature (i.e., vertebral compression fractures or hip fra
ctures after a fall from standing), whereas 8 fractures (36%) were ass
ociated with a significant traumatic event (i.e., a motor vehicle acci
dent, boxing, etc.) and 5 were of mixed etiology. Two of 22 fractures
(9%) were pathologic. CONCLUSIONS, This study demonstrated a 9% fractu
re incidence in a cohort of patients receiving LHRH-a for prostate car
cinoma for up to 96 months. The incidence of osteoporotic fractures wa
s 5%. (C) 1997 American Cancer Society.