E. Palazidou et al., EVIDENCE FOR 5-HYDROXYTRYPTAMINE(1A) RECEPTOR INVOLVEMENT IN THE CONTROL OF PROLACTIN SECRETION IN MAN, Psychopharmacology, 119(3), 1995, pp. 311-314
The effects of pindolol pretreatment (2 days) on prolactin and cortiso
l responses to a single dose of (+)-fenfluramine (30 mg po) were exami
ned in nine healthy male volunteers. Pindolol pretreatment attenuated
the (+)-fenfluramine-induced increase in prolactin concentrations but
failed to affect the (+)-fenfluramine-induced cortisol increase. These
data provide evidence in support of 5-HT1A receptor involvement in th
e regulation of prolactin secretion but question its importance in the
regulation of cortisol secretion in man.