Al. Angiolillo et al., HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO, The Journal of experimental medicine, 182(1), 1995, pp. 155-162
Human interferon-inducible protein 10 (IP-10), a member of the alpha c
hemokine family, inhibits bone marrow colony formation, has antitumor
activity in vivo, is chemoattractant for human monocytes and T cells,
and promotes T cell adhesion to endothelial cells. Here we report that
IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly
inhibited basic fibroblast growth factor-induced neovascularization o
f Matrigel (prepared by H. K. Kleinman) injected subcutaneously into a
thymic mice. In addition, IP-10, in a dose-dependent fashion, suppress
ed endothelial cell differentiation into tubular capillary structures
in vitro. IP-10 had no effect on endothelial cell growth, attachment,
and migration as assayed in vitro. These results document an important
biological property of IP-10 and raise the possibility that IP-10 may
participate in the regulation of angiogenesis during inflammation and
tumorigenesis.