HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO

Citation
Al. Angiolillo et al., HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO, The Journal of experimental medicine, 182(1), 1995, pp. 155-162
Citations number
30
Categorie Soggetti
Immunology,"Medicine, Research & Experimental
ISSN journal
00221007
Volume
182
Issue
1
Year of publication
1995
Pages
155 - 162
Database
ISI
SICI code
0022-1007(1995)182:1<155:HIPIAP>2.0.ZU;2-5
Abstract
Human interferon-inducible protein 10 (IP-10), a member of the alpha c hemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. Here we report that IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly inhibited basic fibroblast growth factor-induced neovascularization o f Matrigel (prepared by H. K. Kleinman) injected subcutaneously into a thymic mice. In addition, IP-10, in a dose-dependent fashion, suppress ed endothelial cell differentiation into tubular capillary structures in vitro. IP-10 had no effect on endothelial cell growth, attachment, and migration as assayed in vitro. These results document an important biological property of IP-10 and raise the possibility that IP-10 may participate in the regulation of angiogenesis during inflammation and tumorigenesis.