SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NEW 3-[(2-FURYL)CARBONYL] AMINO-4-THIAZOLIDINONE AND 2-[(2-FURYL)CARBONYL]HYDRAZONO-4-THIAZOLINE DERIVATIVES

A series of new yl]amino-5-nonsubstituted/methyl-4-thiazolidinones (3) and [(2-furyl)carbonyl]hydrazono-3-alkyl-4-thiazolines (5) was synthe sized and evaluated for anticonvulsant activity against pentylenetetra zole induced seizures. Preliminary results indicated that potency was sensitive to substituents at the 2 and 5 positions of the 4-thiazolidi none and 3 and 4 positions of the 4-thiazoline rings. Among 3, [(2-fur yl)carbonyl]amino-5-methyl-4-thiazolidiones (3e and 3f) and among l]hy drazono-3-allyl-4-(4-bromophenyl)-4-thiazoline (5e), showed the highes t protection (40%).