ALCOHOL AND THE BRAIN - WHATS NO GOT TO DO WITH IT

A potential role for nitric oxide in alcohol-induced changes in brain function is discussed. Chronic alcohol exposure may lead to excitotoxi city partially due to increased levels of nitric oxide (NO). Excessive NO has been linked to cytotoxicity in neurons, glia and myelin. Cytok ines produced in response to cell injury may trigger increased product ion of NO. These events may be involved in alcohol-induced brain damag e. Formation of NO has recently been linked to increased preference fo r and tolerance to alcohol. A hypothesis for prevention and treatment of alcohol-induced brain damage, and craving and alcohol intake by alc oholics is proposed.