ETHAMBUTOL-INDUCED PULMONARY-INFILTRATES WITH EOSINOPHILIA AND SKIN INVOLVEMENT

A 67 year old woman presented with miliary tuberculosis, She was treat ed with streptomycin, isoniazid, rifampicin, ethambutol and pyrazinami de, However, she developed rifampicin-induced thrombocytopenia after 6 weeks of treatment, and skin rash, blood eosinophilia and pulmonary i nfiltrates after 8 weeks of therapy, The latter was found to be ethamb utol related, Additional evidence, including blood and sputum eosinoph ilia and the rapidity of its response to corticosteroid, suggested tha t the pulmonary infiltrates might also be eosinophilic in nature, To t he best of our knowledge, this constitutes the first report of such ad verse drug reaction, induced by ethambutol.