CYP1A1 AND CYP2E1 POLYMORPHISM AND LUNG-CANCER, CASE-CONTROL STUDY INRIO-DE-JANEIRO, BRAZIL

Msp I polymorphism and exon 7 Ile-Val polymorphism of CYP1A1, and Rsa I polymorphism of CYP2E1 were studied in lung cancer patients and cont rols in Rio de Janeiro, Brazil, Of the three polymorphisms studied, on ly the exon 7 polymorphism of CYP1A1 (Val-containing genotypes) had a distribution which was statistically significant in the patients and c ontrols, The contribution of Val containing genotypes of CYP1A1 exon 7 was greater in the subpopulation of squamous cell carcinoma patients with a lower life-time smoking consumption (OR, 2.92 vs 1.97), This as sociation is consistent with the previous findings by Kawajiri et al, and the first observation of the positive association of this locus wi th lung cancer in a Western population (Kawajiri K, Nakachi K, Imai K, Yoshii A, Shimada N, Watanabe J. FEBS Let 1990; 263, 131-133), Furthe rmore, together with the lack of association of Msp I polymorphism in the non-coding region of CYP1A1, the locus truly responsible for lung cancer risk among pleural polymorphisms of CYP1A1 appeared to be exon 7 Ile-Val polymorphism, In the future, investigations of multiple mark ers in different ethnic populations may reveal cancer risk markers com mon to all mankind.