CYTOKINE LOCALIZATION IN MULTIPLE-SCLEROSIS LESIONS - CORRELATION WITH ADHESION MOLECULE EXPRESSION AND REACTIVE NITROGEN SPECIES

The relative levels and cellular distribution of proinflammatory and r egulatory cytokines have been examined by immunohistochemistry in mult iple sclerosis (MS) lesions of differing activity and compared with CN S tissue from other neurologic diseases with an inflammatory or noninf lammatory component. Results show widespread distribution of cytokines in association with both perivascular inflammatory cells and glial ce lls in all types of inflammatory lesions. Although no obvious pattern of proinflammatory versus regulatory cytokines could be determined in MS lesions, proinflammatory cytokines were rarely noted in normal and noninflammatory conditions, whereas regulatory cytokines were readily detectable in the same diseases. The possible relevance of these cytok ine patterns to adhesion molecule expression and the presence of react ive nitrogen species is also addressed.