2 NOVEL METABOLITES IN THE DEGRADATION PATHWAY OF ISOQUINOLINE BY PSEUDOMONAS-DIMINUTA-7

Citation
P. Roger et al., 2 NOVEL METABOLITES IN THE DEGRADATION PATHWAY OF ISOQUINOLINE BY PSEUDOMONAS-DIMINUTA-7, FEMS microbiology letters, 129(2-3), 1995, pp. 281-285
Citations number
16
Categorie Soggetti
Microbiology
Journal title
ISSN journal
03781097
Volume
129
Issue
2-3
Year of publication
1995
Pages
281 - 285
Database
ISI
SICI code
0378-1097(1995)129:2-3<281:2NMITD>2.0.ZU;2-X
Abstract
Pseudomonas diminuta 7 utilizes isoquinoline as sole source of carbon, nitrogen, and energy. Mutagenesis of Psendomonas diminuta 7 with N-me thyl-N'-nitro-N-nitrosoguanidine led to the isolation of two mutants w hich accumulated protocatechuate. Resting cells of wild-type Pseudomon as diminuta 7 produced phthalate as further intermediate of isoquinoli ne degradation. Crude extracts transformed 4,5-dihydroxyphthalate to p rotocatechuate, which was subjected to meta-cleavage. A putative degra dation pathway of isoquinoline is proposed.