INCREASED ERYTHROCYTE CALCIUM-PUMP ACTIVITY IN A KINDRED WITH FAMILIAL BENIGN HYPERCALCEMIA

Authors
ESCOBALES N FARINAS CA HADDOCK L
Citation
N. Escobales et al., INCREASED ERYTHROCYTE CALCIUM-PUMP ACTIVITY IN A KINDRED WITH FAMILIAL BENIGN HYPERCALCEMIA, European journal of clinical investigation, 25(6), 1995, pp. 378-382
Citations number
17
Categorie Soggetti
Medicine, Research & Experimental","Medicine, General & Internal
Journal title
European journal of clinical investigation → ACNP
ISSN journal
00142972
Volume
25
Issue
6
Year of publication
1995
Pages
378 - 382
Database
ISI
SICI code
0014-2972(1995)25:6<378:IECAIA>2.0.ZU;2-M
Abstract
The hypothesis that a global defect in cellular calcium transport may be critical in the development of familial benign hypercalcaemia (FBH) was investigated. Nine hypercalcaemic patients from a kindred with FB H and nine normal subjects were evaluated. Our results indicate that c alcium pump activity in the FBI-I kindred was significantly higher (28 %, P < 0.005) when compared to normal subjects. These findings suggest that alterations in calcium pump activity in activity in target tissu es may play a role in the development of FBH.