INDUCTION OF NET MASS LIPID TRANSFER-REACTIONS IN PLASMA BY WINE CONSUMPTION WITH DINNER

Citation
A. Vantol et al., INDUCTION OF NET MASS LIPID TRANSFER-REACTIONS IN PLASMA BY WINE CONSUMPTION WITH DINNER, European journal of clinical investigation, 25(6), 1995, pp. 390-395
Citations number
31
Categorie Soggetti
Medicine, Research & Experimental","Medicine, General & Internal
ISSN journal
00142972
Volume
25
Issue
6
Year of publication
1995
Pages
390 - 395
Database
ISI
SICI code
0014-2972(1995)25:6<390:IONMLT>2.0.ZU;2-Z
Abstract
Moderate alcohol consumption is associated with a reduced risk of coro nary heart disease. Alcohol may exert protection through its effects o n the metabolism of plasma lipoproteins. In the present study we inves tigated the effects of moderate wine consumption with an evening dinne r on lipoprotein composition and parameters of reverse cholesterol tra nsport (plasma lipid transfer reactions and cholesterol esterification ) in eight healthy middle-aged men. Wine consumption, if compared with mineral water, resulted in increased postprandial plasma levels of tr iglyceride(TG)-rich lipoproteins (P < 0.005 or < 0.002 at two differen t time points) and in increased net mass transfer of cholesterylesters (CE) from high-density lipoprotein (HDL) to apolipoprotein B-containi ng lipoproteins during in vitro incubation of plasma (P < 0.001). Net mass transfer of TG (in the opposite direction) was also significantly increased by wine (P = 0.014). The concentrations of total plasma cho lesterol, HDL-cholesterol and apolipoproteins A-I, A-II and B did not change postprandially and were not affected significantly by wine, but the CE TG(-1) in HDL was affected postprandially and decreased by win e consumption. It is concluded that moderate wine consumption with eve ning dinner induces transfer reactions of CE and TG between HDL and TG -rich lipoproteins. Due to the fact that wine raises plasma TG, it als o causes changes in plasma cholesterol metabolism and lipoprotein comp osition, without major effects on total plasma cholesterol concentrati on.