A. Vantol et al., INDUCTION OF NET MASS LIPID TRANSFER-REACTIONS IN PLASMA BY WINE CONSUMPTION WITH DINNER, European journal of clinical investigation, 25(6), 1995, pp. 390-395
Citations number
31
Categorie Soggetti
Medicine, Research & Experimental","Medicine, General & Internal
Moderate alcohol consumption is associated with a reduced risk of coro
nary heart disease. Alcohol may exert protection through its effects o
n the metabolism of plasma lipoproteins. In the present study we inves
tigated the effects of moderate wine consumption with an evening dinne
r on lipoprotein composition and parameters of reverse cholesterol tra
nsport (plasma lipid transfer reactions and cholesterol esterification
) in eight healthy middle-aged men. Wine consumption, if compared with
mineral water, resulted in increased postprandial plasma levels of tr
iglyceride(TG)-rich lipoproteins (P < 0.005 or < 0.002 at two differen
t time points) and in increased net mass transfer of cholesterylesters
(CE) from high-density lipoprotein (HDL) to apolipoprotein B-containi
ng lipoproteins during in vitro incubation of plasma (P < 0.001). Net
mass transfer of TG (in the opposite direction) was also significantly
increased by wine (P = 0.014). The concentrations of total plasma cho
lesterol, HDL-cholesterol and apolipoproteins A-I, A-II and B did not
change postprandially and were not affected significantly by wine, but
the CE TG(-1) in HDL was affected postprandially and decreased by win
e consumption. It is concluded that moderate wine consumption with eve
ning dinner induces transfer reactions of CE and TG between HDL and TG
-rich lipoproteins. Due to the fact that wine raises plasma TG, it als
o causes changes in plasma cholesterol metabolism and lipoprotein comp
osition, without major effects on total plasma cholesterol concentrati
on.