EXPERIMENTAL-MODELS IN PULMONARY PATHOLOGY

Because of the cellular complexity and spatial organization of the lun g, investigation of the pathogenesis of human pulmonary diseases relie s to a considerable extent upon the use of animal models. In this revi ew, the author examines new models and new applications of existing mo dels of pneumonia, asthma, emphysema, interstitial lung disease and ne oplasms in laboratory mice and rats. Studies of such models may assist in the development of appropriate strategies for early diagnosis and intervention.