CLINDAMYCIN AND METRONIDAZOLE

Clindamycin is active against most anaerobes, most gram-positive cocci (except enterococci and methicillin-resistant staphylococci), and cer tain protozoa. Metronidazole is a bactericidal antibiotic with strong activity against most anaerobes and certain parasites. Both drugs have excellent bioavailability and accomplish good levels in most tissues. Their pharmacology, mechanisms of action and resistance, spectrum of activity, adverse reactions, and expansion of clinical uses are discus sed in this article.