OVARIAN CARCINOMA-ASSOCIATED TAQI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM IN INTRON-G OF THE PROGESTERONE-RECEPTOR GENE IS DUE TO AN ALU SEQUENCE INSERTION

Authors
ROWE SM COUGHLAN SJ MCKENNA NJ GARRETT E KIEBACK DG CARNEY DN HEADON DR
Citation
Sm. Rowe et al., OVARIAN CARCINOMA-ASSOCIATED TAQI RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM IN INTRON-G OF THE PROGESTERONE-RECEPTOR GENE IS DUE TO AN ALU SEQUENCE INSERTION, Cancer research, 55(13), 1995, pp. 2743-2745
Citations number
20
Categorie Soggetti
Oncology
Journal title
Cancer research → ACNP
ISSN journal
00085472
Volume
55
Issue
13
Year of publication
1995
Pages
2743 - 2745
Database
ISI
SICI code
0008-5472(1995)55:13<2743:OCTR>2.0.ZU;2-D
Abstract
Alu sequences, short, repetitive transposable DNA elements, are factor s in a number of genetic diseases, We previously identified a germline TaqI RFLP, located in intron G of the human progesterone receptor gen e, that showed an association with the incidence of sporadic ovarian c arcinoma, Furthermore, the polymorphism was characterized as a small ( similar to 300-bp) insertion that was inherited in a Mendelian fashion , Because of its insertional character, we named this polymorphism PRO GINS. We report the identification of PROGINS as a 306-bp Alu element of the PV or HS-1 Alu subfamily.