Dj. Gaertner et al., PERSISTENT RAT VIRUS-INFECTION IN JUVENILE ATHYMIC RATS AND ITS MODULATION BY IMMUNE SERUM, Laboratory animal science, 45(3), 1995, pp. 249-253
In contrast to euthymic juvenile rats, which develop acute, self-limit
ing infection with rat virus (RV), RV infection of juvenile athymic ra
ts was persistent for up to 12 weeks as demonstrated by recovery of in
fective virus, transmission to cagemates, and detection of viral DNA i
n the lungs. Administration of RV antiserum at the time of virus inocu
lation prevented persistent infection in five of six rats. Among rats
given RV antiserum 1 week after virus, the interval at which euthymic
rats begin to seroconvert, RV was not detected 1 week later but was re
covered from four of six rats 3 weeks later. Results of these studies
confirm that T-cell deficiency facilitates persistent RV infection and
indicate that antibody provides significant protection from persisten
t infection only if it is present at the time of virus inoculation. Th
e results support the concept that factors which prevent persistent in
fection in euthymic rats act early after virus inoculation and may inc
lude cellular immunity.