LOCATION OF AN ATAXIA-TELANGIECTASIA GENE TO AN SIMILAR-TO-500-KB INTERVAL ON CHROMOSOME 11Q23.1 - LINKAGE ANALYSIS OF 176 FAMILIES BY AN INTERNATIONAL CONSORTIUM

Authors
LANGE E BORRESEN AL CHEN XG CHESSA L CHIPLUNKAR S CONCANNON P DANDEKAR S GERKEN S LANGE K LIANG T MCCONVILLE C POLAKOW J PORRAS O ROTMAN G SANAL O SHEIKHAVANDI S SHILOH Y SOBEL E TAYLOR M TELATAR M TERAOKA S TOLUN A UDAR N UHRHAMMER N VANAGAITE L WANG ZJ WAPELHORST B WRIGHT J YANG HM YANG L ZIV Y GATTI RA
Citation
E. Lange et al., LOCATION OF AN ATAXIA-TELANGIECTASIA GENE TO AN SIMILAR-TO-500-KB INTERVAL ON CHROMOSOME 11Q23.1 - LINKAGE ANALYSIS OF 176 FAMILIES BY AN INTERNATIONAL CONSORTIUM, American journal of human genetics, 57(1), 1995, pp. 112-119
Citations number
35
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
57
Issue
1
Year of publication
1995
Pages
112 - 119
Database
ISI
SICI code
0002-9297(1995)57:1<112:LOAAGT>2.0.ZU;2-C
Abstract
We describe a 20-point linkage analysis map of chromosome 11q22-23 tha t is based on genotyping 249 families (59 CEPH and 190 A-T). Monte Car lo linkage analyses of 176 ataxia-telangiectasia (A-T) families locali zes the major A-T locus to the region between S1819(A4) and S1818(A2). When seven nonlinking families were excluded from subsequent analyses , a 2-lod support interval of similar to 500 kb was identified between S1819(A4) and S1294. No recombinants were observed between A-T and ma rkers S384, B7, S535, or S1294. Only 17 of the international consortiu m families have been assigned to complementation groups, The available evidence favors either a cluster of A-T genes on chromosome 11 or int ragenic defects in a single gene.