PURPOSE: To evaluate retrospectively the role of radiation therapy for
extrahepatic bile duct (EHBD) carcinoma. MATERIALS AND METHODS: Twent
y-seven patients with local-regional EHBD carcinomas were treated with
definitive radiation therapy. Radiation therapy was delivered by mean
s of external beam radiation therapy (EBRT) alone or combined with tra
nscatheter iridium-192 brachytherapy. The median total dose was 54 Gy
(range, 30-144 Gy). Survival rates were calculated and compared by usi
ng the log-rank test. Possible prognostic factors affecting survival w
ere evaluated by means of univariate analysis. RESULTS: The median sur
vival of all patients was 13 months, with 1- and 2-year actuarial surv
ival rates of 52% and 10%, respectively. Univariate analysis revealed
that men, patients with tumors limited to the bile duct, and patients
receiving EBRT doses of at least 45 GY had significantly better outcom
es. Local-regional recurrence was the main cause of treatment failure
(82%). Two patients developed gastric outlet obstruction. CONCLUSION:
Patients with locally advanced EHBD carcinomas have a low survival rat
e. Certain factors, however, appear to have prognostic significance.