BIOACTIVE COMPOUNDS FROM TAIWANIA CRYPTOMERIOIDES

Two new sesquiterpenes, 10 alpha-hydroxyamorphan-4-en-3-one (1) and 4 alpha-methylcadinane-4 alpha-methyl-1 alpha,2 alpha,10 alpha-triol (2) , together with four known compounds, sesquiterpenes 10 alpha-hydroxyc adinan-4-en-3-one (3) and alpha-cadinol (4), diterpene ferruginol, and lignan helioxanthin, were isolated from the whole plant of Taiwania c ryptomerioides under bioassay-guided fractionations. The structures of 1 and 2 were elucidated mainly by the NMR spectroscopic analyses. Bio activities of the isolated compounds against brine shrimp, yellow feve r mosquito larvae, and human tumor cells are reported; compound 4 was the most bioactive, showing selectivity for the human colon tumor cell line (HT-29).