The Palauan sponge Luffariella sp. contained manoalide (6) and secoman
oalide (7) as the major metabolites. The minor metabolites, luffastero
ls A-C (3-5), are 9,11-secosterols that contain a 3 beta-acetoxy-5 alp
ha,6 alpha-epoxy-9-oxo-9,11-secocholest-7-en-11-al ring system joined
to three different side chains. The structures of the luffasterols wer
e elucidated by interpretation of spectroscopic data.