SEQUENCE MOTIFS CHARACTERISTIC FOR DNA [CYTOSINE-N4] AND DNA [ADENINE-N6] METHYLTRANSFERASES - CLASSIFICATION OF ALL DNA METHYLTRANSFERASES

Citation
A. Timinskas et al., SEQUENCE MOTIFS CHARACTERISTIC FOR DNA [CYTOSINE-N4] AND DNA [ADENINE-N6] METHYLTRANSFERASES - CLASSIFICATION OF ALL DNA METHYLTRANSFERASES, Gene, 157(1-2), 1995, pp. 3-11
Citations number
25
Categorie Soggetti
Genetics & Heredity
Journal title
GeneACNP
ISSN journal
03781119
Volume
157
Issue
1-2
Year of publication
1995
Pages
3 - 11
Database
ISI
SICI code
0378-1119(1995)157:1-2<3:SMCFD[>2.0.ZU;2-S
Abstract
Two additional conserved motifs (CM), CM Is and CM III, have been foun d in addition to well-known CM I and CM II within the primary amino ac id sequences of almost all m(6)A- and m(4)C-methyltransferases (MTases ). The boundaries of all four CM were defined and their consensus sequ ences characteristic both for different classes, as well as for all N- MTases, were derived. Some regular deviations at fixed positions of th e consensus sequences CM Is, CM I and CM II, typical for separate clas ses of N-MTases, were presumed to correlate. A possible structural bas is for the supposed interregional correlations is discussed and experi ments for verification of the assumed interactions between CM are sugg ested. A classification scheme for all N-MTases is provided.