T. Yamaoka et al., COMPARISON OF BODY DISTRIBUTION OF POLY(VINYL ALCOHOL) WITH OTHER WATER-SOLUBLE POLYMERS AFTER INTRAVENOUS ADMINISTRATION, Journal of Pharmacy and Pharmacology, 47(6), 1995, pp. 479-486
The body distribution of poly(vinyl alcohol) (PVA) with molecular weig
hts (MW) from 14800 to 434000 Da was investigated after intravenous ad
ministration and compared with that of other water-soluble polymers su
ch as poly(ethylene glycol) (PEG), gelatin, dextran, and pullulan. The
half-life of PVA in the circulation was prolonged from 90 min (MW 148
00Da) to 23 h (MW 434000 Da), similar to that of PEG which had a half-
life of 30 min (MW 6000) and 20 h (MW 170000). However, the half-life
of PVA was much longer than that of other polymers when compared at a
similar molecular weight. PVA was located in most organs but with very
small accumulation. An insignificant interaction of PVA with cell com
ponents, such as macrophages and blood cells, was observed. Similar to
PEG, the excretion rate of PVA at the glomeruli was rapidly reduced a
round 30000 Da, as the molecular weight increased. These results indic
ate that the half-life of intravenously injected PVA in the blood was
mainly determined by the permeation characteristics of the kidney.