STRESS PROTEINS - THE EXERCISE RESPONSE

A class of proteins that under-goes preferential synthesis following a variety of stressors has been demonstrated to carry out important cel lular-functions under both stressed and nonstressed conditions. These so-called heal shock (HSP) or stress (SP) proteins have been termed '' molecular chaperones'' and play important roles in cellular transporta tion, assembly/degradation, and cell survival. This review provides a basic introduction to the function and regulation of these proteins. E mphasis is placed on members of the HSP 70 family of proteins (especia lly HSP 72) and their role in cellular protection, their pattern of di stribution in skeletal muscle, and changes in their expression followi ng exercise and exercise training.