RECENT ADVANCES IN CYTOMETRY, CYTOGENETICS AND MOLECULAR-GENETICS OF THYROID-TUMORS AND TUMOR-LIKE LESIONS

In this review we summarize the most recent advances of flow and image cytometry, cytogenetics and molecular genetics of tumours and tumour- like lesions of the thyroid, especially focusing on the putative relat ionship between nodular goitres and adenomas, the differential diagnos is of benign and malignant neoplasms and the pathogenesis and prognosi s of carcinomas. Data obtained by in situ hybridization and immunohist ochemical detection of proliferative markers, metal binding proteins a nd oncogenes, anti-oncogenes, growth factors and growth factor recepto rs are also used whenever appropriate.