PLATELET SULFOTRANSFERASE IN DIFFERENT PSYCHIATRIC-DISORDERS

The aim of our study was to measure and compare platelet phenolsulfotr ansferase (PST) activity in patients affected by different psychiatric disorders and in healthy volunteers. The results showed that the acti vity of both of the two forms of PST was significantly higher in 30 pa tients with obsessive-compulsive disorder and in 25 manic patients tha n in 20 healthy volunteers. On the contrary, normal values were found in 11 dysthymic patients, 12 bipolar depressives, and 14 patients with panic disorder, whereas lower values were found in 12 unipolar depres sives and 30 patients with migraine. It would therefore seem that diff erent neuropsychiatric disorders are associated with different levels of PST activity. Copyright (C) 1996 Elsevier Science Ireland Ltd.