CHOLESTATIC PRURITUS - PATHOPHYSIOLOGY AN D THERAPY WITH SPECIAL CONCERN ON ITS TREATMENT WITH 5-HYDROXYTRYPTAMINE SUBTYPE-3 RECEPTOR ANTAGONISTS

Authors
SCHWORER H RAMADORI G
Citation
H. Schworer et G. Ramadori, CHOLESTATIC PRURITUS - PATHOPHYSIOLOGY AN D THERAPY WITH SPECIAL CONCERN ON ITS TREATMENT WITH 5-HYDROXYTRYPTAMINE SUBTYPE-3 RECEPTOR ANTAGONISTS, Zeitschrift fur Gastroenterologie, 33(5), 1995, pp. 265-274
Citations number
163
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Zeitschrift fur Gastroenterologie → ACNP
ISSN journal
00442771
Volume
33
Issue
5
Year of publication
1995
Pages
265 - 274
Database
ISI
SICI code
0044-2771(1995)33:5<265:CP-PAD>2.0.ZU;2-6
Abstract
Our current knowledge about the pathophysiology of pruritus (itch) is summarized. Special concern is given to the hypotheses to explain itch due to cholestatic liver diseases (bile acids, generation of hepatic and intestinal pruritogens, endogenous opioids). Drugs used for the tr eatment of cholestatic itch are discussed in detail. On the basis of s uccessful treatment of cholestatic itch with 5-hydroxytryptamine (sero tonin) subtype-3 receptor antagonists the role of serotonin in nocicep tion is discussed.