MEMBRANOUS GLOMERULONEPHRITIS ASSOCIATED WITH TESTICULAR SEMINOMA

Proteinuria, often nephrotic in range, is a recognized paraneoplastic syndrome of solid tumours, with membranous glomerulonephritis (MGN) th e most common histopathological lesion seen on renal biopsy. A 56-year -old male was found to have proteinuria on routine medical examination . History, physical and serological evaluation failed to reveal an aet iology and subsequent renal biopsy showed MGN, presumed to be idiopath ic. Prednisone therapy was begun but this proteinuria did not resolve (> 1g 24 h(-1)). Eleven months later the patient discovered a testicul ar mass which was found to be a stage I seminoma upon excision and met astatic evaluation. His proteinuria rapidly normalized after orchectom y and regional lymph node radiotherapy. This is the first known case o f MGN associated with testicular seminoma.