ENHANCEMENT BY TNF-ALPHA OF REACTIVATION AND REPLICATION OF LATENT HERPES-SIMPLEX VIRUS FROM TRIGEMINAL GANGLIA OF MICE

Authors
WALEV I PODLECH J FALKE D
Citation
I. Walev et al., ENHANCEMENT BY TNF-ALPHA OF REACTIVATION AND REPLICATION OF LATENT HERPES-SIMPLEX VIRUS FROM TRIGEMINAL GANGLIA OF MICE, Archives of virology, 140(6), 1995, pp. 987-992
Citations number
20
Categorie Soggetti
Virology
Journal title
Archives of virology → ACNP
ISSN journal
03048608
Volume
140
Issue
6
Year of publication
1995
Pages
987 - 992
Database
ISI
SICI code
0304-8608(1995)140:6<987:EBTORA>2.0.ZU;2-Z
Abstract
The influence of tumor-necrosis-factor-alpha (TNF-alpha), granulocytem acrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) an d IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-alpha and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivat ion frequency and replication of HSV. Interferon alpha/beta (IFN alpha /beta)prevented reactivation and replication.