STUDIES ON NEW PHOSPHODIESTERASE INHIBITORS .1. SYNTHESIS OF 1-(2,3-EPOXYPROPOXY)-2(4)-FLUOROBENZENES AND 1-(2-HYDROXY-3-MORPHOLINOPROPOXY AND PIPERAZINO)FLUOROBENZENE DERIVATIVES

Authors
BAKER NR BYRNE NG ECONOMIDES AP JAVED T
Citation
Nr. Baker et al., STUDIES ON NEW PHOSPHODIESTERASE INHIBITORS .1. SYNTHESIS OF 1-(2,3-EPOXYPROPOXY)-2(4)-FLUOROBENZENES AND 1-(2-HYDROXY-3-MORPHOLINOPROPOXY AND PIPERAZINO)FLUOROBENZENE DERIVATIVES, Chemical and Pharmaceutical Bulletin, 43(6), 1995, pp. 1045-1048
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
6
Year of publication
1995
Pages
1045 - 1048
Database
ISI
SICI code
0009-2363(1995)43:6<1045:SONPI.>2.0.ZU;2-G
Abstract
A series of 1-(2,3-epoxypropoxy)-2(4)-fluorobenzenes and their corresp onding 1-(2-hydroxy-3-morpholino propoxy and piperazino)fluorobenzene derivatives (8a-f) were synthesised via a short synthetic route in goo d chemical yields and were evaluated for inotropic and chronotropic ac tivity in isolated guinea-pig atria preparation. The compounds act as potential phosphodiesterase (PDE) inhibitors with desirable biological activity and have considerable promise in heart therapy.