RELATION DOSE INTENSITY IN CHEMOTHERAPY - THE EXAMPLE OF BREAST-CANCER

The efficacy of cytotoxic chemotherapy when administred at conventiona l doses in breast cancer is limited and allows to understand some fail ures in the adjuvant, advanced or inflammatory and also in metastatic settings. The use of high dose chemotherapy is one way ro try to impro ve its efficacy based on response rare, overall and disease free survi val. Retrospective analysis on dose efficacy Ca breast cancer suggest that the results obtained by cytotoxic chemotherapy are linked to the administered dose without being able to assess this hypothesis with ce rtainty. In 1995, the concept of dose efficacy remains to be validated by the appropriate prospective randomized trials.