In order to investigate the genetic basis for the observed polymorphis
m amongst meningococcal transferrin-binding proteins, Tbp2, the corres
ponding genes of different Neisseria meningitidis strains were cloned
and sequenced. Comparison of the deduced amino acid (aa) sequences ind
icated that the Tbp2 were 76.6 to 81.2% homologous. Several stretches
of aa have been found repeated both in the N- and C-terminal halves of
the molecule.