Chordomas and chondrosarcomas are uncommon skull base tumors that are
locally aggressive. Chordomas arise from the clivus with the epicenter
in the midline of the skull base. Chondrosarcomas, in contrast, usual
ly arise along the petro-occipital fissure. Occasionally, a chondrosar
coma may be revealed in a midline location and then cannot be differen
tiated from chordoma. Chordomas rarely calcify whereas calcification i
s not an uncommon finding in chondrosarcomas. The prognoses of chordom
as and chondrosarcomas vary. Long-term survival is usually seen with c
hondrosarcomas but is still considerably compromised with chordomas.