THE INTERTUMORAL HETEROGENEITY IN DRUG-SE NSITIVITY OF CELLS FROM THEPRIMARY TUMOR AND ASCITIC FLUID IN HUMAN OVARIAN-CANCER

For tumor cells isolated from 25 samples of ovarian cancer tissue and from 35 samples of ascitic fluid of 47 patients 255 curves <<cytostati c dose effect>> are obtained by MTT-assay and analysed. In 1/3 of case s the presence of cell subpopulations with different drug sensitivity was ascertained. The comparative clinical efficiency of cytostatics ir e the series platidiam-thio-TEPA - adriablastin - 5-fluorouracil - vin cristine is negatively correlated with frequency of the presence of th e resistant subpopulation to the corresponding drug. The subpopulation structure of tumor cells from primary tumor and from ascitic fluid is different in large number of cases (50.0+/-8.1%). In most of these ca ses the difference is based on the preferential silting of cells resis tant to some cytostatics to ascitic fluid.