INTERACTION OF ANTHRACYCLINE ANTIBIOTICS AND PLATINUM-CONTAINING DRUGS WITH TISSUE THIOL-GROUPS IN INTACT ANIMALS

The interaction of anthracycline antibiotics and platinum-containing d rugs with tissue thiol groups (SH-groups) has been studied in intact r ats and mice. There has been established the lowering of SH-group cont ent within the first hours after drug administration. The extent of an titumor drugs interaction with SH-groups correlated with organ specifi city. Platinum-containing drugs possessed high extent of SH-group inac tivation in renal tissue, whereas anthracycline antibiotics, adriablas tin in particular, exerted more pronounced effect in myocardial tissue . The administration of antitumor drugs inhibited glutathion-reductase activity in blood of animals to a considerable extent, it being an ev idence of the enhancement of peroxidation, the diminishing of glutathi on synthesis and consequently, of the decline of organism resistance t o toxic influence.