INDIVIDUAL PECULIARITIES OF THE EXCRETION OF BENZO[-ALPHA]PYRENE, METABOLITES AND A CARCINOGENIC EFFECT FOLLOWING ITS MULTIPLE INTRAPERITONEAL ADMINISTRATIONS

In the rats exposed to ten intraperitoneal injections of benzo[a]pyren e (BP) in a form of water-lipid emulsion, a total dose of 100 mg/kg, i ndividual diferences in the levels of excretion of BP bioactivation pr oduct, BP-7,8-diol, and a product of its detoxication, 5-hydroxy-BP, w ere found. Tumors of internal organs, i.e. lung lymphosarcoma and peri toneal malignant fibrous histiocytomas developed in 10 per cent of rat s. These animals excreted with the urine more BP-7,8-diol, than the ra ts without the tumors of internal organs. A possibility of prediction of individual susceptibility to BP among the persons, who have occupat ional or domestic contact with BP-containing products, is discussed.