THE SUBRENAL CAPSULE ASSAY FOR DETERMINAT ION OF PRIMARY DRUG-RESISTANCE OF THE ESOPHAGEAL TUMORS

Authors
STOROZHENKO IV SKOTNIKOVA OI SERGEYEVA NS CHISSOV VI BORISOV VI LVOVA EV AKHMEDOVA SA MAMONTOV AS
Citation
Iv. Storozhenko et al., THE SUBRENAL CAPSULE ASSAY FOR DETERMINAT ION OF PRIMARY DRUG-RESISTANCE OF THE ESOPHAGEAL TUMORS, Eksperimental'naa onkologia, 16(4-6), 1994, pp. 461-463
Citations number
9
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
16
Issue
4-6
Year of publication
1994
Pages
461 - 463
Database
ISI
SICI code
0204-3564(1994)16:4-6<461:TSCAFD>2.0.ZU;2-A
Abstract
By means of subrenal capsule assay (SCA) the sensitivity of 18 esophag eal squamous cell carcinoma to 7 antineoplastic agents (cyclophosphane , methotrexate, cisplatin, adriablastine, 5-fluoruracil, prospidine, b leomycin) was investigated. The primary multidrug resistance was estab lished for more than 50% of the tumors. The majority of the tumors in SCA were resistant to cyclophosphane and adriablastine. The number of tumors sensitive to 5-fluoruracil was 50.0+/-11.8%, to cisplatin - 27. 8+/-10.6% and to methotrexate - 27.8+/-10.6%.