ACUTE MYELOMONOCYTIC LEUKEMIA IN A PATIENT WITH MULTIPLE-MYELOMA - EVIDENCE FOR DIFFERENT CLONAL ORIGIN

Authors
NAKASE K TSUJI K HASEGAWA M SUZUKI Y TAMAKI S TANIGAWA M IKEDA T MIYANISHI E
Citation
K. Nakase et al., ACUTE MYELOMONOCYTIC LEUKEMIA IN A PATIENT WITH MULTIPLE-MYELOMA - EVIDENCE FOR DIFFERENT CLONAL ORIGIN, Internal medicine, 34(6), 1995, pp. 546-549
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
Internal medicine → ACNP
ISSN journal
09182918
Volume
34
Issue
6
Year of publication
1995
Pages
546 - 549
Database
ISI
SICI code
0918-2918(1995)34:6<546:AMLIAP>2.0.ZU;2-R
Abstract
A case of 77-year-old female with multiple myeloma (IgG-k) developed a cute myelomonocytic leukemia (AMMoL) following a myelodysplastic stage after chemotherapy with melphalan-cyclophosphamide combinations for 6 years, The leukemic blast cells expressed both myeloid antigens (CD11 b, CD13, CD14, CD15, CD33 and CD34) and TIE lymphoid antigens (CD2, CD 4, CD22 and PCA1), Cytogenetic analysis revealed a chromosome deletion -7, Analysis of immunoglobulin genes showed the heavy chain genes in germ line configuration, These findings indicate that the AMMoL was a therapy-related stem cell leukemia acid was a clonal origin geneticall y different from multiple myeloma irrespective of plasma cell phenotyp e.