A hypercalcemic patient with adult T-cell leukemia was treated with de
oxycoformycin (DCF) in a dose of 5 mg/m(2) daily for three days, Sever
al days later, severe thrombocytopenia appeared abruptly and then micr
oangiopathic hemolytic anemia ensued, Subsequently, renal failure and
hypertension developed, and the patient died seven weeks after DCF the
rapy, Needle necropsy of the kidney showed glomerular damage including
swelling of endothelial cells, mesangiolysis and segmental collapse,
This is the second reported case of hemolytic-uremic syndrome due to D
CF.