HEMOLYTIC-UREMIC SYNDROME DUE TO DEOXYCOFORMYCIN - A REPORT OF THE 2ND CASE

Citation
C. Sakai et al., HEMOLYTIC-UREMIC SYNDROME DUE TO DEOXYCOFORMYCIN - A REPORT OF THE 2ND CASE, Internal medicine, 34(6), 1995, pp. 593-596
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
09182918
Volume
34
Issue
6
Year of publication
1995
Pages
593 - 596
Database
ISI
SICI code
0918-2918(1995)34:6<593:HSDTD->2.0.ZU;2-3
Abstract
A hypercalcemic patient with adult T-cell leukemia was treated with de oxycoformycin (DCF) in a dose of 5 mg/m(2) daily for three days, Sever al days later, severe thrombocytopenia appeared abruptly and then micr oangiopathic hemolytic anemia ensued, Subsequently, renal failure and hypertension developed, and the patient died seven weeks after DCF the rapy, Needle necropsy of the kidney showed glomerular damage including swelling of endothelial cells, mesangiolysis and segmental collapse, This is the second reported case of hemolytic-uremic syndrome due to D CF.