HEMOLYTIC-UREMIC SYNDROME DUE TO DEOXYCOFORMYCIN - A REPORT OF THE 2ND CASE

A hypercalcemic patient with adult T-cell leukemia was treated with de oxycoformycin (DCF) in a dose of 5 mg/m(2) daily for three days, Sever al days later, severe thrombocytopenia appeared abruptly and then micr oangiopathic hemolytic anemia ensued, Subsequently, renal failure and hypertension developed, and the patient died seven weeks after DCF the rapy, Needle necropsy of the kidney showed glomerular damage including swelling of endothelial cells, mesangiolysis and segmental collapse, This is the second reported case of hemolytic-uremic syndrome due to D CF.