2 METHODS FOR THE PREPARATION OF 3-DIALKYLAMINOMETHYL DERIVATIVES (MANNICH-BASES) OF 4-AMINOCOUMARIN - A NEW-TYPE OF INTRAMOLECULAR HYDRIDETRANSFER

Authors
IVANOV IC KARAGIOSOV SK
Citation
Ic. Ivanov et Sk. Karagiosov, 2 METHODS FOR THE PREPARATION OF 3-DIALKYLAMINOMETHYL DERIVATIVES (MANNICH-BASES) OF 4-AMINOCOUMARIN - A NEW-TYPE OF INTRAMOLECULAR HYDRIDETRANSFER, Synthesis, (6), 1995, pp. 633-634
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
6
Year of publication
1995
Pages
633 - 634
Database
ISI
SICI code
0039-7881(1995):6<633:2MFTPO>2.0.ZU;2-8
Abstract
The transformation of 4-alkylaminocoumarin-3-carbaldehydes (1 b-f) by treatment with secondary amines 2 a-i into 3-dialkylaminomethyl-4-amin ocoumarins 4 a-i via intramolecular hydride transfer is reported. The structure of 4 was ascertained by independent Mannich reaction of 4-am inocoumarin (5) yielding the 3-dialkylaminomethyl derivatives 4 a-e. B y treatment of 1 e with primary amine 6 only the usual Schiff base 7 w as obtained.