CLINICAL AND MICROBIOLOGICAL EVALUATION OF PEFLOXACIN IN LOWER RESPIRATORY-TRACT INFECTIONS

Citation
G. Tatsis et al., CLINICAL AND MICROBIOLOGICAL EVALUATION OF PEFLOXACIN IN LOWER RESPIRATORY-TRACT INFECTIONS, Journal of international medical research, 24(6), 1996, pp. 478-481
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
ISSN journal
03000605
Volume
24
Issue
6
Year of publication
1996
Pages
478 - 481
Database
ISI
SICI code
0300-0605(1996)24:6<478:CAMEOP>2.0.ZU;2-W
Abstract
Patients with Gram-negative lower respiratory tract infections (acute exacerbation of chronic bronchitis (n = 23), pneumonia (n = 4), and br onchiectasis (n = 5) were treated with pefloxacin, 400 mg twice daily, given either intravenously or orally. Symptoms, signs and sputum volu me and colour were monitored daily, Chest X-rays, sputum culture and G ram-stain examinations were carried out on days 1 and 5, and immediate ly alter the end of the treatment. There was a clinical improvement, a s indicated by the incidence of cough, dyspnoea and rales, and by sput um volume and colour in 31 patients (97%). Microbiological improvement . as indicated by the complete elimination of sputum pathogens and pus cells, was achieved in 28 of the patients (88%), In one patient, an a dverse effect, renal failure, occurred. These results suggest that pef loxacin is both clinically and microbiologically effective for the tre atment of Gram-negative lower respiratory tract infections.