SYNTHESIS AND ANTITUMOR-ACTIVITY OF QUATERNARY-SALTS OF 2-(2'-OXOALKOXY)-9-HYDROXYELLIPTICINES

Authors
HARADA N KAWAGUCHI T INOUE I OHASHI M ODA K HASHIYAMA T TSUJIHARA K
Citation
N. Harada et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF QUATERNARY-SALTS OF 2-(2'-OXOALKOXY)-9-HYDROXYELLIPTICINES, Chemical and Pharmaceutical Bulletin, 45(1), 1997, pp. 134-137
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
1
Year of publication
1997
Pages
134 - 137
Database
ISI
SICI code
0009-2363(1997)45:1<134:SAAOQO>2.0.ZU;2-D
Abstract
Various kinds of water-soluble quaternary salts of 2-(2'-oxoalkoxy)-9- hydroxyellipticines were synthesized in a search for compounds with po tent antitumor activity and low toxicity. Some compounds exhibited mor e potent antitumor activities than elliptinium (1) and SUN 4599 (3). I n particular, -hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazolium bromi de (4d) showed potent antitumor activities against P388 leukemia, colo n 26, and Lewis lung carcinoma.