STUDIES ON THE CONSTITUENTS OF SCUTELLARIA SPECIES .18. STRUCTURES OFNEOCLERODANE-TYPE DITERPENOIDS FROM THE WHOLE HERB OF SCUTELLARIA-RIVULARIS WALL

Authors
KIZU H IMOTO Y TOMIMORI T KIKUCHI T KADOTA S TSUBONO K
Citation
H. Kizu et al., STUDIES ON THE CONSTITUENTS OF SCUTELLARIA SPECIES .18. STRUCTURES OFNEOCLERODANE-TYPE DITERPENOIDS FROM THE WHOLE HERB OF SCUTELLARIA-RIVULARIS WALL, Chemical and Pharmaceutical Bulletin, 45(1), 1997, pp. 152-160
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
1
Year of publication
1997
Pages
152 - 160
Database
ISI
SICI code
0009-2363(1997)45:1<152:SOTCOS>2.0.ZU;2-B
Abstract
Five neoclerodane-type diterpenoid lactones, scuterivulactones A, B, C -1, C-2 and D, have been isolated (scuterivulactone C-2 was separated as the acetate) from the whole herb of Scutellaria rivularis WALL. (La biaceae), and their structures have been determined based on chemical and physicochemical evidence as follows: scuterivulactone A, (4S,11S)- 11-acetoxy-6 alpha benzoyloxy-3,4-epoxy-8 beta-hydroxy-13(14)-neoclero den-15,16-olide; scuterivulactone B, (4R,13R)-11 beta-acetoxy-6 alpha- benzoyloxy-8 beta,13-epoxy-3-oxo-15,16-neoclerodanolide; scuterivulact one C-1, (4R,13R)-11 beta-acetosy-6 alpha-benzoyloxy-3 alpha,4 beta-di hydroxy-8 beta,13-epoxy-15,16-neoclerodanolide; scuterivulactone C-2, (4R,13S*)-11 beta-acetoxy-6 alpha-benzoyloxy-3 alpha,4 beta-dihydroxy -8 beta,13-epoxy-15,16-neoclerodanolide; and scuterivulactone D, (4R)- 6 alpha-benzoyloxy-3 alpha,4 ta-dihydroxy-11,13(14)-neoclerodadien-15, 16-olide.