Ea. Innes et Jm. Wastling, ANALYSIS OF IN-VIVO IMMUNE-RESPONSES DURING TOXOPLASMA-GONDII INFECTION USING THE TECHNIQUE OF LYMPHATIC CANNULATION, Parasitology today, 11(7), 1995, pp. 268-271
A major obstacle in the design of effective inactivated vaccines is th
e induction of an appropriate immune response in the recipient Direct
examination of immune responses induced in vivo following infection is
possible using the technique of lymphatic cannulation. This allows a
unique insight into the development of the immune response to Particul
ar pathogens and provides important information that could be exploite
d in the design of suitable vaccine delivery systems in order to induc
e and maintain appropriate protective immune responses. In this articl
e, Elisabeth Innes and Jonathan Wastling review studies involving the
use of lymphatic cannulation to examine immune responses induced in vi
vo during infection of sheep with the S48 strain of Toxoplasma gondii,
which is currently used as a vaccine against toxoplasmosis for veteri
nary use only.