TEL-AVIV HEIDELBERG 3-GENERATION OFFSPRING STUDY - GENETIC-DETERMINANTS OF APOLIPOPROTEIN A1 AND APOLIPOPROTEIN-B

The contribution of major gene and multifactorial effects on variation of plasma apolipoproteins Al and B has been tested in a large sample of population-based Israeli pedigrees, Our most parsimonious and best fitting model for both apolipoproteins is consistent with Mendelian tr ansmissibility, with significant contribution of major genes (with 2 a lleles recessive and dominant within each locus) and polygenes, but ne glects effects of common sib environment as well as related intergener ation differences in polygenic effects. Total genetic effects explain 71 and 58% of phenotypic variance of APO-A1 and APO-B levels. The majo r genes account for about 44 and 32% of the variance in APO-A1 and APO -B, respectively, and the frequency of the recessive alleles determini ng the high level of apolipoproteins under the study in the Israeli po pulation is in the vicinity of 40% at each locus. (C) 1995 Wiley-Liss, Inc.